Haloferax volcanii —a model archaeon for studying DNA replication and repair | Zendy

Patricia Pérez-Arnaiz | Zendy; Ambika Dattani | Zendy; Victoria Smith | Zendy; Thorsten Allers | Zendy

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Haloferax volcanii —a model archaeon for studying DNA replication and repair

Author(s) -

Patricia Pérez-Arnaiz,

Ambika Dattani,

Victoria Smith,

Thorsten Allers

Publication year - 2020

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.200293

Subject(s) - haloferax volcanii , biology , archaea , dna replication , euryarchaeota , three domain system , halophile , model organism , genetics , computational biology , bacteria , phylum , evolutionary biology , dna , gene

The tree of life shows the relationship between all organisms based on their common ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by Carl Woese and other microbiologists led to the recategorization of prokaryotes and the proposal of three primary domains: Eukarya, Bacteria and Archaea. Microbiological, genetic and biochemical techniques were then needed to study the third domain of life. Haloferax volcanii , a halophilic species belonging to the phylum Euryarchaeota, has provided many useful tools to study Archaea, including easy culturing methods, genetic manipulation and phenotypic screening. This review will focus on DNA replication and DNA repair pathways in H. volcanii , how this work has advanced our knowledge of archaeal cellular biology, and how it may deepen our understanding of bacterial and eukaryotic processes.

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