Insight into m 6 A methylation from occurrence to functions | Zendy

Wenxiu Ru | Zendy; Xiaoyan Zhang | Zendy; Binglin Yue | Zendy; Ao Qi | Zendy; Xuemei Shen | Zendy; Yongzhen Huang | Zendy; Xianyong Lan | Zendy; Chuzhao Lei | Zendy; Hong Chen | Zendy

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Insight into m ⁶ A methylation from occurrence to functions

Author(s) -

Wenxiu Ru,

Xiaoyan Zhang,

Binglin Yue,

Ao Qi,

Xuemei Shen,

Yongzhen Huang,

Xianyong Lan,

Chuzhao Lei,

Hong Chen

Publication year - 2020

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.200091

Subject(s) - biology , methylation , genetics , gene

RNA m 6 A methylation is a post-transcriptional modification that occurs at the nitrogen-6 position of adenine. This dynamically reversible modification is installed, removed and recognized by methyltransferases, demethylases and readers, respectively. This modification has been found in most eukaryotic mRNA, tRNA, rRNA and other non-coding RNA. Recent studies have revealed important regulatory functions of the m 6 A including effects on gene expression regulation, organism development and cancer development. In this review, we summarize the discovery and features of m 6 A, and briefly introduce the mammalian m 6 A writers, erasers and readers. Finally, we discuss progress in identifying additional functions of m 6 A and the outstanding questions about the regulatory effect of this widespread modification.

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