The multifarious regulation of the apical junctional complex | Zendy

Alexandra D. Rusu | Zendy; Μάριος Γεωργίου | Zendy

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The multifarious regulation of the apical junctional complex

Author(s) -

Alexandra D. Rusu,

Μάριος Γεωργίου

Publication year - 2020

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.190278

Subject(s) - adherens junction , biology , cell junction , microbiology and biotechnology , cell polarity , tight junction , cadherin , cell adhesion , septate junctions , polarity (international relations) , gap junction , intracellular , cell–cell interaction , cell , epithelial polarity , adhesion , genetics , chemistry , organic chemistry

Epithelial cells form highly organized polarized sheets with characteristic cell morphologies and tissue architecture. Cell–cell adhesion and intercellular communication are prerequisites of such cohesive sheets of cells, and cell connectivity is mediated through several junctional assemblies, namely desmosomes, adherens, tight and gap junctions. These cell–cell junctions form signalling hubs that not only mediate cell–cell adhesion but impact on multiple aspects of cell behaviour, helping to coordinate epithelial cell shape, polarity and function. This review will focus on the tight and adherens junctions, constituents of the apical junctional complex, and aims to provide a comprehensive overview of the complex signalling that underlies junction assembly, integrity and plasticity.

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