Open AccessEmerging microRNA biomarkers for colorectal cancer diagnosis and prognosis
Author(s) -
Bing Chen,
Zijing Xia,
Yanan Deng,
Yang Yang,
Peng Zhang,
Hongxia Zhu,
Nuo Xu
Publication year - 2019
Publication title -
open biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.078
H-Index - 53
ISSN - 2046-2441
DOI - 10.1098/rsob.180212
Subject(s) - microrna , biology , colorectal cancer , carcinogenesis , oncogene , cancer , suppressor , computational biology , bioinformatics , cancer research , gene , genetics , cell cycle
MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.