AMP-activated protein kinase: a therapeutic target in intestinal diseases | Zendy

Xiaofei Sun | Zendy; Meijun Zhu | Zendy

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AMP-activated protein kinase: a therapeutic target in intestinal diseases

Author(s) -

Xiaofei Sun,

Meijun Zhu

Publication year - 2017

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.170104

Subject(s) - ampk , amp activated protein kinase , autophagy , biology , protein kinase a , adenosine monophosphate , inflammation , cancer research , microbiology and biotechnology , kinase , apoptosis , adenosine , immunology , endocrinology , biochemistry

Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, nutrient transporters, autophagy and apoptosis, and suppresses inflammation and carcinogenesis in the intestine, indicating an essential role of AMPK in intestinal health. AMPK inactivation is an aetiological factor in intestinal dysfunctions. This review summarizes the favourable outcomes of AMPK activation on intestinal health, and discusses AMPK as a potential therapeutic target for intestinal diseases.

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