Recent advances in dynamic m 6 A RNA modification

The identification of m 6 A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m 6 A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m 6 A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the ‘writers’, ‘erasers’ and ‘readers’ of m 6 A RNA modification. Moreover, we emphasize recent advances of biological functions of m 6 A and conceive the possible roles of m 6 A in the regulation of immune response and related diseases.