There is no ‘Conundrum’ of InsP 6 | Zendy

Robin F. Irvine | Zendy; Simon J. Bulley | Zendy; Miranda Wilson | Zendy; Adolfo Saiardi | Zendy

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There is no ‘Conundrum’ of InsP ₆

Author(s) -

Robin F. Irvine,

Simon J. Bulley,

Miranda Wilson,

Adolfo Saiardi

Publication year - 2015

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.150181

Subject(s) - biology , dephosphorylation , inositol , phosphatase , biochemistry , microbiology and biotechnology , phosphorylation , receptor

Indirect assays have claimed to quantify phytate (InsP6) levels in human biofluids, but these have been based on the initial assumption that InsP6 is there, an assumption that our more direct assays disprove. We have shown that InsP6 does not and cannot (because of the presence of an active InsP6 phosphatase in serum) exist in mammalian serum or urine. Therefore, any physiological effects of dietary InsP6 can only be due either to its actions in the gut as a polyvalent cation chelator, or to inositol generated by its dephosphorylation by gut microflora.

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