The miR-302/367 cluster: a comprehensive update on its evolution and functions | Zendy

Zeqian Gao | Zendy; Xueliang Zhu | Zendy; Yongxi Dou | Zendy

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The miR-302/367 cluster: a comprehensive update on its evolution and functions

Author(s) -

Zeqian Gao,

Xueliang Zhu,

Yongxi Dou

Publication year - 2015

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.150138

Subject(s) - biology , reprogramming , microrna , epigenetics , embryonic stem cell , computational biology , regulation of gene expression , gene cluster , cluster (spacecraft) , gene , transcriptional regulation , epigenesis , genetics , gene expression , microbiology and biotechnology , evolutionary biology , dna methylation , computer science , programming language

microRNAs are a subclass of small non-coding RNAs that fine-tune the regulation of gene expression at the post-transcriptional level. The miR-302/367 cluster, generally consisting of five members, miR-367, miR-302d, miR-302a, miR-302c and miR-302b, is ubiquitously distributed in vertebrates and occupies an intragenic cluster located in the gene La-related protein 7 ( LARP7 ). The cluster was demonstrated to play an important role in diverse biological processes, such as the pluripotency of human embryonic stem cells (hESCs), self-renewal and reprogramming. This paper provides an overview of the mir-302/367 cluster, discusses our current understanding of the cluster's evolutionary history and transcriptional regulation and reviews the literature surrounding the cluster's roles in cell cycle regulation, epigenetic regulation and different cellular signalling pathways.

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