The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter | Zendy

Jingyu Deng | Zendy; Liang Han | Zendy; Qiuping Dong | Zendy; Yachao Hou | Zendy; Xingming Xie | Zendy; Jun Yu | Zendy; Daiming Fan | Zendy; Xishan Hao | Zendy

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The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter

Author(s) -

Jingyu Deng,

Liang Han,

Qiuping Dong,

Yachao Hou,

Xingming Xie,

Jun Yu,

Daiming Fan,

Xishan Hao

Publication year - 2014

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.140067

Subject(s) - biology , cpg site , dna methylation , methylation , promoter , bisulfite sequencing , cancer research , microbiology and biotechnology , cancer , lymphoma , gene , epigenetics , b cell lymphoma , bisulfite , genetics , immunology , gene expression

The methylation of B-cell CLL/lymphoma 6 member B (BCL6B) DNA promoter was detected in several malignancies. Here, we quantitatively detect the methylated status of CpG sites of BCL6B DNA promoter of 459 patients with gastric cancer (GC) by using bisulfite gene sequencing. We show that patients with three or more methylated CpG sites in the BCL6B promoter were significantly associated with poor survival. Furthermore, by using the Akaike information criterion value calculation, we show that the methylated count of BCL6B promoter was identified to be the optimal prognostic predictor of GC patients.

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