Exotic mitotic mechanisms | Zendy

Hauke Drechsler | Zendy; Andrew D. McAinsh | Zendy

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Exotic mitotic mechanisms

Author(s) -

Hauke Drechsler,

Andrew D. McAinsh

Publication year - 2012

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.120140

Subject(s) - biology , mitosis , chromosome segregation , kinetochore , chromosome , microbiology and biotechnology , eukaryotic chromosome fine structure , microtubule , evolutionary biology , genetics , computational biology , gene

The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from ‘mainstream’ mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis.

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