Drosophilaas a model system to unravel the layers of innate immunity to infection | Zendy

Ilias Kounatidis | Zendy; Petros Ligoxygakis | Zendy

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Drosophilaas a model system to unravel the layers of innate immunity to infection

Author(s) -

Ilias Kounatidis,

Petros Ligoxygakis

Publication year - 2012

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.120075

Subject(s) - biology , innate immune system , drosophila melanogaster , effector , immunity , drosophila (subgenus) , pattern recognition receptor , acquired immune system , innate lymphoid cell , immune system , computational biology , immunology , genetics , gene

Summary Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host–pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.

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