A cell-based mechanical model of coronary artery tunica media | Zendy

N.B. Melnikova | Zendy; Andrew Svitenkov | Zendy; D. Rodney Hose | Zendy; Alfons G. Hoekstra | Zendy

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A cell-based mechanical model of coronary artery tunica media

Author(s) -

N.B. Melnikova,

Andrew Svitenkov,

D. Rodney Hose,

Alfons G. Hoekstra

Publication year - 2017

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2017.0028

Subject(s) - tunica media , hertz , anisotropy , materials science , tunica intima , softening , mechanics , anatomy , composite material , physics , smooth muscle , optics , medicine , carotid arteries , quantum mechanics

A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal close-packed lattice. Tissue anisotropy is taken into account by varying interaction forces with the direction of intercellular connection. Several cell-centre interaction potentials for repulsion and attraction are considered, including the Hertz contact model and its neo-Hookean extension, the Johnson–Kendall–Roberts model of adhesive contact, and a wormlike chain model. The model is validated against data fromin vitro uni-axial tension tests performed on dissected strips of tunica media. The wormlike chain potential in combination with the neo-Hookean Hertz contact model produces stress–stretch curves which represent the experimental data very well.

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