An integrated approach to quantitative modelling in angiogenesis research | Zendy

Anthony J. Connor | Zendy; Radosław P. Nowak | Zendy; Erica Lorenzon | Zendy; Markus Thomas | Zendy; Frank Herting | Zendy; Stefan Hoert | Zendy; Tom Quaiser | Zendy; Eliezer Shochat | Zendy; Joe PittFrancis | Zendy; Jonathan Cooper | Zendy; Philip K. Maini | Zendy; Helen M. Byrne | Zendy

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An integrated approach to quantitative modelling in angiogenesis research

Author(s) -

Anthony J. Connor,

Radosław P. Nowak,

Erica Lorenzon,

Markus Thomas,

Frank Herting,

Stefan Hoert,

Tom Quaiser,

Eliezer Shochat,

Joe PittFrancis,

Jonathan Cooper,

Philip K. Maini,

Helen M. Byrne

Publication year - 2015

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2015.0546

Subject(s) - angiogenesis , context (archaeology) , basic fibroblast growth factor , computer science , vascular endothelial growth factor , cornea , process (computing) , parametrization (atmospheric modeling) , experimental data , mathematical model , biological system , vegf receptors , computational biology , growth factor , biology , neuroscience , mathematics , cancer research , biochemistry , physics , paleontology , statistics , receptor , quantum mechanics , radiative transfer , operating system

Angiogenesis, the process by which new vessels form from existing ones, plays an important role in many developmental processes and pathological conditions. We study angiogenesis in the context of a highly controllable experimental environment: the cornea micropocket assay. Using a multidisciplinary approach that combines experiments, image processing and analysis, and mathematical modelling, we aim to provide mechanistic insight into the action of two angiogenic factors, vascular endothelial growth factor A (VEGF-A) and basic fibroblast growth factor (bFGF).We use image analysis techniques to extract quantitative data,which are both spatially and temporally resolved, from experimental images, and we develop a mathematical model, in which the corneal vasculature evolves in response to both VEGF-A and bFGF. The experimental data are used for model parametrization, while the mathematical model is used to assess the utility of the cornea micropocket assay and to characterize proposed synergies between VEGF-A and bFGF

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