Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds | Zendy

Juan Pablo Cattalini | Zendy; Alexander Hoppe | Zendy; Fatemehsadat Pishbin | Zendy; J. Roether | Zendy; Aldo R. Boccaccını | Zendy; Silvia Lucangioli | Zendy; Viviana Mouriño | Zendy

Open Access

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Author(s) -

Juan Pablo Cattalini,

Alexander Hoppe,

Fatemehsadat Pishbin,

J. Roether,

Aldo R. Boccaccını,

Silvia Lucangioli,

Viviana Mouriño

Publication year - 2015

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2015.0509

Subject(s) - nanocomposite , tissue engineering , biomedical engineering , materials science , mesenchymal stem cell , scaffold , umbilical vein , bioactive glass , matrigel , biomaterial , swelling , chemistry , in vitro , nanotechnology , composite material , microbiology and biotechnology , biochemistry , medicine , biology

This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu2+ or Ca2+ (AlgNbgCu, AlgNbgCa, respectively). Two-dimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu2+ and Ca2+ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu2+ or Ca2+ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

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