Hyperpolarized 83 Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema | Zendy

David M.L. Lilburn | Zendy; Clémentine Lesbats | Zendy; Joseph S. Six | Zendy; Eric Dubuis | Zendy; Liang YewBooth | Zendy; Dominick Shaw | Zendy; Maria G. Belvisi | Zendy; Mark A. Birrell | Zendy; Galina E. Pavlovskaya | Zendy; Thomas Meersmann | Zendy

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Hyperpolarized ⁸³ Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema

Author(s) -

David M.L. Lilburn,

Clémentine Lesbats,

Joseph S. Six,

Eric Dubuis,

Liang YewBooth,

Dominick Shaw,

Maria G. Belvisi,

Mark A. Birrell,

Galina E. Pavlovskaya,

Thomas Meersmann

Publication year - 2015

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2015.0192

Subject(s) - magnetic resonance imaging , isotope , nuclear magnetic resonance , volume (thermodynamics) , chemistry , relaxation (psychology) , square (algebra) , nuclear medicine , elastase , materials science , physics , medicine , radiology , mathematics , nuclear physics , thermodynamics , geometry , enzyme

Hyperpolarized (83)Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method uses the nuclear electric properties of the spin I = 9/2 isotope (83)Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase-induced model of emphysema. A significant (83)Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase-treated lungs compared with the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface-to-volume ratio in the emphysema model that was validated by histology. The finding supports usage of (83)Kr SQUARE as a new biomarker for surface-to-volume ratio changes in emphysema.

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