Gold-containing bioactive glasses: a solid-state synthesis to produce alternative biomaterials for bone implantations | Zendy

Valentina Aina | Zendy; G. Cerrato | Zendy; Gianmario Martra | Zendy; Loredana Bergandi | Zendy; Costanzo Costamagna | Zendy; Dario Ghigo | Zendy; Gianluca Malavasi | Zendy; Gigliola Lusvardi | Zendy; Ledi Menabue | Zendy

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Gold-containing bioactive glasses: a solid-state synthesis to produce alternative biomaterials for bone implantations

Author(s) -

Valentina Aina,

G. Cerrato,

Gianmario Martra,

Loredana Bergandi,

Costanzo Costamagna,

Dario Ghigo,

Gianluca Malavasi,

Gigliola Lusvardi,

Ledi Menabue

Publication year - 2013

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2012.1040

Subject(s) - colloidal gold , nanoparticle , transmission electron microscopy , materials science , bioactive glass , chemical engineering , ceramic , nanotechnology , biocompatibility , nuclear chemistry , chemistry , metallurgy , composite material , engineering

A new melted bioactive system containing gold nanoparticles (AuNPs) was prepared exploiting a post-synthesis thermal treatment that allows one to modify crystal phases and nature, shape and distribution of the gold species in the glass-ceramic matrix as evidenced by UV-visible spectroscopy, transmission electron microscopy and powder X-ray diffraction analysis. In human MG-63 osteoblasts the presence of Aun+ species caused an increase of lactate dehydrogenase leakage and malonyldialdehyde production, whereas Hench's Bioglass HAu-600-17 containing only AuNPs did not cause any effect. In addition, HAu-600-17 caused in vitro hydroxyapatite formation and an increase of specific surface area with a controlled release of gold species; this material is then suitable to be used as a model system for the controlled delivery of nanoparticles

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