Unstable eigenmodes are possible drivers for cardiac arrhythmias | Zendy

Aslak Tveito | Zendy; Glenn Terje Lines | Zendy; Ola Skavhaug | Zendy; Mary M. Maleckar | Zendy

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Unstable eigenmodes are possible drivers for cardiac arrhythmias

Author(s) -

Aslak Tveito,

Glenn Terje Lines,

Ola Skavhaug,

Mary M. Maleckar

Publication year - 2011

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2011.0152

Subject(s) - heartbeat , cardiology , qrs complex , ventricular fibrillation , medicine , contraction (grammar) , fibrillation , electrocardiography , normal sinus rhythm , physics , atrial fibrillation , computer science , computer security

The well-organized contraction of each heartbeat is enabled by an electrical wave traversing and exciting the myocardium in a regular manner. Perturbations to this wave, referred to as arrhythmias, can lead to lethal fibrillation if not treated within minutes. One manner in which arrhythmias originate is an ill-fated interaction of the regular electrical signal controlling the heartbeat, the sinus wave, with an ectopic stimulus. It is not fully understood how and when ectopic waves are generated. Based on mathematical models, we show that ectopic beats can be characterized in terms of unstable eigenmodes of the resting state.

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