Quiescence: a mechanism for escaping the effects of drug on cell populations | Zendy

Tomás Alarcón | Zendy; Henrik Jeldtoft Jensen | Zendy

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Quiescence: a mechanism for escaping the effects of drug on cell populations

Author(s) -

Tomás Alarcón,

Henrik Jeldtoft Jensen

Publication year - 2010

Publication title -

journal of the royal society interface

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.655

H-Index - 139

eISSN - 1742-5689

pISSN - 1742-5662

DOI - 10.1098/rsif.2010.0130

Subject(s) - extinction (optical mineralogy) , organism , population , biology , tipping point (physics) , ecology , mechanism (biology) , reproductive success , small population size , evolutionary biology , demography , genetics , engineering , philosophy , epistemology , sociology , habitat , electrical engineering , paleontology

We point out that a simple and generic strategy in order to lower the risk for extinction consists in developing a dormant stage in which the organism is unable to multiply but may die. The dormant organism is protected against the poisonous environment. The result is to increase the survival probability of the entire population by introducing a type of zero reproductive fitness. This is possible, because the reservoir of dormant individuals act as a buffer that can cushion fatal fluctuations in the number of births and deaths, which without the dormant population would have driven the entire population to extinction.

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