A novel workflow for three-dimensional analysis of tumour cell migration | Zendy

Sophie Ketchen | Zendy; Arndt Rohwedder | Zendy; Sabine Knipp | Zendy; Filomena Esteves | Zendy; Nina Struve | Zendy; Michelle Peckham | Zendy; John E. Ladbury | Zendy; Alistair Curd | Zendy; Susan Short | Zendy; Anke BrüningRichardson | Zendy

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A novel workflow for three-dimensional analysis of tumour cell migration

Author(s) -

Sophie Ketchen,

Arndt Rohwedder,

Sabine Knipp,

Filomena Esteves,

Nina Struve,

Michelle Peckham,

John E. Ladbury,

Alistair Curd,

Susan Short,

Anke BrüningRichardson

Publication year - 2020

Publication title -

interface focus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 49

eISSN - 2042-8901

pISSN - 2042-8898

DOI - 10.1098/rsfs.2019.0070

Subject(s) - workflow , computer science , plug in , data science , computational biology , biology , database , programming language

The limitations of two-dimensional analysis in three-dimensional (3D) cellular imaging impair the accuracy of research findings in biological studies. Here, we report a novel 3D approach to acquisition, analysis and interpretation of tumour spheroid images. Our research interest in mesenchymal–amoeboid transition led to the development of a workflow incorporating the generation and analysis of 3D data with instant structured illumination microscopy and a new ImageJ plugin.

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