Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer
Author(s) -
Ján Tkáč,
Veronika Gajdošová,
Štefánia Hrončeková,
Tomáš Bertók,
Michal Híreš,
Eduard Jáné,
Lenka Lorencová,
Peter Kasák
Publication year - 2019
Publication title -
interface focus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 49
eISSN - 2042-8901
pISSN - 2042-8898
DOI - 10.1098/rsfs.2018.0077
Subject(s) - prostate cancer , prostate specific antigen , biomarker , medicine , cancer , prostate , oncology , antigen , immunology , biology , biochemistry
The initial part of this review details the controversy behind the use of a serological level of prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel biomarkers are in demand for PCa diagnostics, outperforming traditional PSA tests. The review provides a detailed and comprehensive summary that PSA glycoprofiling can effectively solve this problem, thereby considerably reducing the number of unnecessary biopsies. In addition, PSA glycoprofiling can serve as a prognostic PCa biomarker to identify PCa patients with an aggressive form of PCa, avoiding unnecessary further treatments which are significantly life altering (incontinence or impotence).
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