Liquid–liquid phase separation in artificial cells | Zendy

Charles D. Crowe | Zendy; Christine D. Keating | Zendy

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Liquid–liquid phase separation in artificial cells

Author(s) -

Charles D. Crowe,

Christine D. Keating

Publication year - 2018

Publication title -

interface focus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 49

eISSN - 2042-8901

pISSN - 2042-8898

DOI - 10.1098/rsfs.2018.0032

Subject(s) - compartmentalization (fire protection) , separation (statistics) , computer science , liquid liquid , phase (matter) , artificial cell , biological system , biochemical engineering , chemistry , biology , chromatography , machine learning , biochemistry , engineering , organic chemistry , membrane , enzyme

Liquid–liquid phase separation (LLPS) in biology is a recently appreciated means of intracellular compartmentalization. Because the mechanisms driving phase separations are grounded in physical interactions, they can be recreated within less complex systems consisting of only a few simple components, to serve as artificial microcompartments. Within these simple systems, the effect of compartmentalization and microenvironments upon biological reactions and processes can be studied. This review will explore several approaches to incorporating LLPS as artificial cytoplasms and in artificial cells, including both segregative and associative phase separation.

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