Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention | Zendy

Alexander Galkin | Zendy; Salvador Moncada | Zendy

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Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention

Author(s) -

Alexander Galkin,

Salvador Moncada

Publication year - 2017

Publication title -

interface focus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 49

eISSN - 2042-8901

pISSN - 2042-8898

DOI - 10.1098/rsfs.2016.0104

Subject(s) - mitochondrion , nitric oxide , reactive oxygen species , microbiology and biotechnology , conformational change , chemistry , complex oxide , bioinformatics , medicine , computational biology , neuroscience , biophysics , biochemistry , biology , oxide , organic chemistry

In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.

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