Surface modification and cellular uptake evaluation of Au-coated Ni 80 Fe 20 nanodiscs for biomedical applications | Zendy

Gabriele Barrera | Zendy; Loredana Serpe | Zendy; Federica Celegato | Zendy; Marco Coїsson | Zendy; Katia Martina | Zendy; Roberto Canaparo | Zendy; P. Tiberto | Zendy

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Surface modification and cellular uptake evaluation of Au-coated Ni ₈₀ Fe ₂₀ nanodiscs for biomedical applications

Author(s) -

Gabriele Barrera,

Loredana Serpe,

Federica Celegato,

Marco Coїsson,

Katia Martina,

Roberto Canaparo,

P. Tiberto

Publication year - 2016

Publication title -

interface focus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 49

eISSN - 2042-8901

pISSN - 2042-8898

DOI - 10.1098/rsfs.2016.0052

Subject(s) - nucleation , materials science , nanolithography , remanence , nanotechnology , layer (electronics) , nanoparticle , polystyrene , magnetization , fabrication , chemical engineering , chemistry , composite material , magnetic field , medicine , physics , alternative medicine , organic chemistry , pathology , quantum mechanics , engineering , polymer

A nanofabrication technique based on self-assembling of polystyrene nanospheres is used to obtain magnetic Ni80Fe20 nanoparticles with a disc shape. The free-standing nanodiscs (NDs) have diameter and thickness of about 630 nm and 30 nm, respectively. The versatility of fabrication technique allows one to cover the ND surface with a protective gold layer with a thickness of about 5 nm. Magnetization reversal has been studied by room-temperature hysteresis loop measurements in water-dispersed free-standing NDs. The reversal shows zero remanence, high susceptibility and nucleation/annihilation fields due to spin vortex formation. In order to investigate their potential use in biomedical applications, the effect of NDs coated with or without the protective gold layer on cell growth has been evaluated. A successful attempt to bind cysteine-fluorescein isothiocyanate (FITC) derivative to the gold surface of magnetic NDs has been exploited to verify the intracellular uptake of the NDs by cytofluorimetric analysis using the FITC conjugate.

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