Bioinspired genotype–phenotype linkages: mimicking cellular compartmentalization for the engineering of functional proteins | Zendy

Liisa van Vliet | Zendy; Pierre-Yves Colin | Zendy; Florian Hollfelder | Zendy

Open Access

Bioinspired genotype–phenotype linkages: mimicking cellular compartmentalization for the engineering of functional proteins

Author(s) -

Liisa van Vliet,

Pierre-Yves Colin,

Florian Hollfelder

Publication year - 2015

Publication title -

interface focus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 49

eISSN - 2042-8901

pISSN - 2042-8898

DOI - 10.1098/rsfs.2015.0035

Subject(s) - compartmentalization (fire protection) , protein engineering , computational biology , synthetic biology , phenotype , directed evolution , biology , nanotechnology , chemistry , computer science , enzyme , biochemistry , materials science , gene , mutant

The idea of compartmentalization of genotype and phenotype in cells is key for enabling Darwinian evolution. This contribution describes bioinspired systems that use in vitro compartments—water-in-oil droplets and gel-shell beads—for the directed evolution of functional proteins. Technologies based on these principles promise to provide easier access to protein-based therapeutics, reagents for processes involving enzyme catalysis, parts for synthetic biology and materials with biological components.

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