A model of ionic transport and osmotic volume control in cochlear outer hair cells | Zendy

Timothy O. West | Zendy; Jonathan Ashmore | Zendy

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A model of ionic transport and osmotic volume control in cochlear outer hair cells

Author(s) -

Timothy O. West,

Jonathan Ashmore

Publication year - 2014

Publication title -

interface focus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 49

eISSN - 2042-8901

pISSN - 2042-8898

DOI - 10.1098/rsfs.2014.0018

Subject(s) - prestin , hair cell , biophysics , cochlea , intracellular , ion transporter , chemistry , flux (metallurgy) , microbiology and biotechnology , membrane , biology , biochemistry , neuroscience , organic chemistry

A computational model of the outer hair cell (OHC) of the mammalian cochlea is presented. It addresses the way in which movement of ions controls the cell shape and regulates pH. The model takes into account the possible chloride-bicarbonate exchange function of prestin, a protein highly expressed in the plasma membrane of OHCs. A model of intracellular pH transients following the imposition of a rapid acid load upon the cell has been adapted from the squid axon literature and further extended in order to investigate the effects of ion transport upon the osmotic flux of water into the cell. The model predicts the slow length changes of OHCs reported in the literature a feature which may control the contribution of OHCs to cochlear amplification.

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