Lighting up cells with lanthanide self-assembled helicates | Zendy

JeanClaude G. Bünzli | Zendy

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Lighting up cells with lanthanide self-assembled helicates

Author(s) -

JeanClaude G. Bünzli

Publication year - 2013

Publication title -

interface focus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.1

H-Index - 49

eISSN - 2042-8901

pISSN - 2042-8898

DOI - 10.1098/rsfs.2013.0032

Subject(s) - lanthanide , photobleaching , luminescence , nanotechnology , microfluidics , bioconjugation , chemistry , fluorescence , materials science , optoelectronics , physics , organic chemistry , optics , ion

Lanthanide bioprobes and bioconjugates are ideal luminescent stains in view of their low propensity to photobleaching, sharp emission lines and long excited state lifetimes permitting time-resolved detection for enhanced sensitivity. We show here how the interplay between physical, chemical and biochemical properties allied to microfluidics engineering leads to self-assembled dinuclear lanthanide luminescent probes illuminating live cells and selectively detecting biomarkers expressed by cancerous human breast cells.

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