Open AccessAxonal Degeneration in Peripheral Nerves in a Case of Leber Hereditary Optic Neuropathy
Author(s) -
Lilit Mnatsakanyan,
Fred N. RossCisneros,
Valerio Carelli,
Michelle Wang,
Alfredo A. Sadun
Publication year - 2011
Publication title -
journal of neuro-ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.586
H-Index - 55
eISSN - 1536-5166
pISSN - 1070-8022
DOI - 10.1097/wno.0b013e3181fab1b4
Subject(s) - peripheral neuropathy , leber's hereditary optic neuropathy , medicine , pathology , optic neuropathy , axonal degeneration , mitochondrial dna , anatomy , optic nerve , peripheral , biology , diabetes mellitus , endocrinology , genetics , gene
Leber hereditary optic neuropathy (LHON) is a mitochondrial DNA (mtDNA) genetic disorder characterized by profound bilateral loss of central vision due to selective loss of retinal ganglion cells. Most patients with LHON do not have complaints related to the peripheral nervous system. We investigated possible qualitative and quantitative histological changes in the peripheral nerve of a patient with LHON as compared to normal controls.