Inhibitory Effects of Belatacept on Allospecific Regulatory T-Cell Generation in Humans | Zendy

Josh Levitsky | Zendy; Joshua Miller | Zendy; Xuemei Huang | Zendy; Dhivya Chandrasekaran | Zendy; Li Chen | Zendy; James M. Mathew | Zendy

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Inhibitory Effects of Belatacept on Allospecific Regulatory T-Cell Generation in Humans

Author(s) -

Josh Levitsky,

Joshua Miller,

Xuemei Huang,

Dhivya Chandrasekaran,

Li Chen,

James M. Mathew

Publication year - 2013

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31829f1607

Subject(s) - belatacept , mixed lymphocyte reaction , flow cytometry , transplantation , immunology , in vitro , interleukin 7 receptor , mycophenolate , antigen , pharmacology , cytotoxic t cell , lymphocyte , t cell , immune system , biology , il 2 receptor , medicine , biochemistry , kidney transplantation , kidney transplant

It is unclear if new costimulatory blockade agents, such as the cytotoxic T lymphocyte-associated antigen 4-Ig molecule belatacept (BEL), promote or inhibit the potential for immunologic tolerance in transplantation. We therefore tested the in vitro effects of BEL on human regulatory T cells (Tregs) in mixed lymphocyte reactions (MLR) alone and in combination with maintenance agents used in transplant recipients.

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