Open AccessInhibitory Effects of Belatacept on Allospecific Regulatory T-Cell Generation in Humans
Author(s) -
Josh Levitsky,
Joshua Miller,
Xuemei Huang,
Dhivya Chandrasekaran,
Li Chen,
James M. Mathew
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31829f1607
Subject(s) - belatacept , mixed lymphocyte reaction , flow cytometry , transplantation , immunology , in vitro , interleukin 7 receptor , mycophenolate , antigen , pharmacology , cytotoxic t cell , lymphocyte , t cell , immune system , biology , il 2 receptor , medicine , biochemistry , kidney transplantation , kidney transplant
It is unclear if new costimulatory blockade agents, such as the cytotoxic T lymphocyte-associated antigen 4-Ig molecule belatacept (BEL), promote or inhibit the potential for immunologic tolerance in transplantation. We therefore tested the in vitro effects of BEL on human regulatory T cells (Tregs) in mixed lymphocyte reactions (MLR) alone and in combination with maintenance agents used in transplant recipients.