Open AccessPodocyte Effacement Closely Links to suPAR Levels at Time of Posttransplantation Focal Segmental Glomerulosclerosis Occurrence and Improves With Therapy
Author(s) -
Nada Alachkar,
Changli Wei,
Lois J. Arend,
Annette M. Jackson,
Lorraine C. Racusen,
Alessia Fori,
George W. Burke,
Hamid Rabb,
Kavita Kakkad,
Jochen Reiser,
Michelle M. Estrella
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31829eda4f
Subject(s) - supar , focal segmental glomerulosclerosis , podocyte , medicine , glomerulosclerosis , glomerulonephritis , proteinuria , receptor , kidney , urokinase receptor
Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS.