Open AccessElevated Pretransplantation Soluble BAFF Is Associated With an Increased Risk of Acute Antibody-Mediated Rejection
Author(s) -
Gemma D. Banham,
Davide Prezzi,
Sarah K. Harford,
Craig Taylor,
Rizwan Hamer,
Rob Higgins,
J. Andrew Bradley,
Menna R. Clatworthy
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318298dd65
Subject(s) - b cell activating factor , medicine , antibody , transplantation , immunology , cytokine , tumor necrosis factor alpha , b cell
B cells play an important role in renal allograft pathology, particularly in acute and chronic antibody-mediated rejection (AMR). B-cell activating factor belonging to the tumor necrosis factor family (BAFF; also known as BLyS) is a cytokine that enhances B-cell survival and proliferation.