Human Hepatic Stellate Cells Inhibit T-Cell Response Through B7-H1 Pathway | Zendy

Ronald Charles | Zendy; Hong-Shiue Chou | Zendy; Lianfu Wang | Zendy; John J. Fung | Zendy; Lina Lü | Zendy; Shiguang Qian | Zendy

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Human Hepatic Stellate Cells Inhibit T-Cell Response Through B7-H1 Pathway

Author(s) -

Ronald Charles,

Hong-Shiue Chou,

Lianfu Wang,

John J. Fung,

Lina Lü,

Shiguang Qian

Publication year - 2013

Publication title -

transplantation

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e318294caae

Subject(s) - hepatic stellate cell , microbiology and biotechnology , liver cytology , cell , chemistry , cancer research , immunology , biology , medicine , pathology , liver metabolism , biochemistry

The liver is an immunologic privileged organ; liver allografts are accepted across major histocompatibility complex barriers in many species. However, hepatocyte transplants are acutely rejected, suggesting a role for liver nonparenchymal cells in regulating the immunoresponse. We have shown potent immunoregulatory activity of hepatic stellate cells (HSCs) in mice. The aim of this study was to examine the immunoregulatory activity of human HSCs.

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