Open AccessUpregulation of IL-1β, IL-6, and CCL-2 by a Novel Mouse Model of Pancreatic Ischemia-Reperfusion Injury
Author(s) -
Keri E. Lunsford,
Brandon J. Baird,
Gregory D. Sempowski,
Diana M. Cardona,
Zhiguo Li,
Kent J. Weinhold,
Debra Sudan,
Todd V. Brennan
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318286483a
Subject(s) - chemokine , proinflammatory cytokine , downregulation and upregulation , inflammation , medicine , cytokine , pancreas , reperfusion injury , immunology , endocrinology , ischemia , biology , biochemistry , gene
Little is known about the immunologic events surrounding pancreatic ischemia-reperfusion injury (IRI) because of a lack of established experimental models. The purpose of this study was to develop a mouse model for pancreatic IRI to serve as a basis for the immunologic characterization of pancreatic organ damage at transplantation.