Open AccessInsulin-Like Growth Factor-II (IGF-II) Prevents Proinflammatory Cytokine-Induced Apoptosis and Significantly Improves Islet Survival After Transplantation
Author(s) -
Amy Hughes,
Daisy Mohanasundaram,
Svjetlana Kireta,
Claire F. Jessup,
Chris Drogemuller,
P. Toby Coates
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31827fa453
Subject(s) - islet , transplantation , insulin like growth factor , endocrinology , biology , medicine , apoptosis , proinflammatory cytokine , cytokine , growth factor , programmed cell death , immunology , cancer research , insulin , inflammation , receptor , biochemistry
The early loss of functional islet mass (50-70%) due to apoptosis after clinical transplantation contributes to islet allograft failure. Insulin-like growth factor (IGF)-II is an antiapoptotic protein that is highly expressed in β-cells during development but rapidly decreases in postnatal life.