CYP3A5 Gene Variation Influences Cyclosporine A Metabolite Formation and Renal Cyclosporine Disposition | Zendy

Songmao Zheng | Zendy; Yasar Tasnif | Zendy; Mary F. Hébert | Zendy; Connie L. Davis | Zendy; Yoshihisa Shitara | Zendy; Justina C. Calamia | Zendy; Yvonne S. Lin | Zendy; Danny D. Shen | Zendy; Kenneth E. Thummel | Zendy

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CYP3A5 Gene Variation Influences Cyclosporine A Metabolite Formation and Renal Cyclosporine Disposition

Author(s) -

Songmao Zheng,

Yasar Tasnif,

Mary F. Hébert,

Connie L. Davis,

Yoshihisa Shitara,

Justina C. Calamia,

Yvonne S. Lin,

Danny D. Shen,

Kenneth E. Thummel

Publication year - 2013

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31827e6ad9

Subject(s) - metabolite , disposition , variation (astronomy) , cyp3a5 , pharmacology , biology , gene , medicine , genetics , psychology , genotype , social psychology , physics , astrophysics

Higher concentrations of AM19 and AM1c9, secondary metabolites of cyclosporine A (CsA), have been associated with nephrotoxicity in organ transplant patients. The risk of renal toxicity may depend on the accumulation of CsA and its metabolites in the renal tissue. We evaluated the hypothesis that CYP3A5 genotype, and inferred enzyme expression, affects systemic CsA metabolite exposure and intrarenal CsA accumulation.

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