Open AccessIncreased Plasma Levels of Microparticles Expressing CD39 and CD133 in Acute Liver Injury
Author(s) -
Moritz Schmelzle,
Katrin Splith,
Lars W. Andersen,
Miroslaw Kornek,
Detlef Schuppan,
Caitlin Jones-Bamman,
Michael D. Nowak,
Vasilis Toxavidis,
Steven D. Salhanick,
Lihui Han,
J. am Esch,
Sven Jonas,
Michael W. Donnino,
Simon C. Robson
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318278d3cd
Subject(s) - liver injury , medicine , inflammation , acetaminophen , endocrinology , immunology , andrology , gastroenterology , pharmacology
We have previously demonstrated that CD133 and CD39 are expressed by hematopoietic stem cells (HSC), which are mobilized after liver injury and target sites of injury, limit vascular inflammation, and boost hepatic regeneration. Plasma microparticles (MP) expressing CD39 can block endothelial activation. Here, we tested whether CD133 MP might be shed in a CD39-dependent manner in a model of liver injury and could potentially serve as biomarkers of liver failure in the clinic.