Open AccessCritical Role for IL-17A/F in the Immunopathogenesis of Obliterative Airway Disease Induced by Anti-MHC I Antibodies
Author(s) -
Haseeb Ilias Basha,
S. Ramachandran,
Venkataswarup Tiriveedhi,
Motoi Takenaka,
Vijay Subramanian,
Dilip S. Nath,
N. Benshoff,
G.A. Patterson,
Thalachallour Mohanakumar
Publication year - 2013
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3182772244
Subject(s) - immunology , antibody , disease , medicine , interleukin 17 , airway , immune system , pathology , surgery
The IL-17 axis is implicated in pathogenesis of chronic rejection after human lung transplantation. Using a murine model of obliterative airway disease (OAD), we recently demonstrated that Abs to MHC class I antigens can induce immune responses to self-antigens that contributes to immunopathogenesis of chronic rejection. Using a murine model of OAD, we determined the role of IL-17 family members in induction of autoimmunity leading to OAD after ligation of MHC class I.