Critical Role for IL-17A/F in the Immunopathogenesis of Obliterative Airway Disease Induced by Anti-MHC I Antibodies | Zendy

Haseeb Ilias Basha | Zendy; Sabarinathan Ramachandran | Zendy; Venkataswarup Tiriveedhi | Zendy; Masashi Takenaka | Zendy; Vijay Subramanian | Zendy; Dilip S. Nath | Zendy; N. Benshoff | Zendy; G.A. Patterson | Zendy; Thalachallour Mohanakumar | Zendy

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Critical Role for IL-17A/F in the Immunopathogenesis of Obliterative Airway Disease Induced by Anti-MHC I Antibodies

Author(s) -

Haseeb Ilias Basha,

Sabarinathan Ramachandran,

Venkataswarup Tiriveedhi,

Masashi Takenaka,

Vijay Subramanian,

Dilip S. Nath,

N. Benshoff,

G.A. Patterson,

Thalachallour Mohanakumar

Publication year - 2012

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3182772244

Subject(s) - immunology , antibody , disease , medicine , interleukin 17 , airway , immune system , pathology , surgery

The IL-17 axis is implicated in pathogenesis of chronic rejection after human lung transplantation. Using a murine model of obliterative airway disease (OAD), we recently demonstrated that Abs to MHC class I antigens can induce immune responses to self-antigens that contributes to immunopathogenesis of chronic rejection. Using a murine model of OAD, we determined the role of IL-17 family members in induction of autoimmunity leading to OAD after ligation of MHC class I.

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