Open AccessTolerogenicity of Donor Major Histocompatibility Complex–Matched Skin Grafts in Previously Tolerant Massachusetts General Hospital Miniature Swine
Author(s) -
Joshua Weiner,
Joseph R. Scalea,
Yoshinori Ishikawa,
Masayoshi Okumi,
Adam Griesemer,
Akito Hirakata,
Justin Etter,
B. Gillon,
Shan Moran,
Akira Shimizu,
Kazuhiko Yamada,
David H. Sachs
Publication year - 2012
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31827254f5
Subject(s) - medicine , immunosuppression , sensitization , immune tolerance , transplantation , immunology , immunologic tolerance , skin grafting , antigen , major histocompatibility complex , surgery
Long-term tolerance of class I disparate renal allografts in miniature swine can be induced by a short course of cyclosporine and persists for 3 to 4 months after grafts are removed. Donor class I peptide immunization 6 weeks after graftectomy of tolerated kidneys leads to sensitization, but donor skin grafts do not. Here, we tested the hypothesis that skin grafts prevent rejection after simultaneous peptide administration and skin grafting.