Open AccessImmunoregulatory Function of IL-27 and TGF-β1 in Cardiac Allograft Transplantation
Author(s) -
Laëtitia Le Texier,
Paméla Thébault,
Manuela Carvalho-Gaspar,
Virginie Vignard,
Emmanuel Mérieau,
Claire Usal,
MariaCristina Cuturi,
Kathryn J. Wood,
Elise Chiffoleau
Publication year - 2012
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31825b0c38
Subject(s) - transforming growth factor , transplantation , immunosuppression , biology , immune tolerance , immunology , microbiology and biotechnology , cancer research , immune system , medicine
Deciphering the mechanisms of tolerance represents a crucial aim of research in transplantation. We previously identified by DNA chip interleukin (IL)-27 p28 and transforming growth factor (TGF)-β1 as overexpressed in a model of rat cardiac allograft tolerance mediated by regulatory CD4CD25 T cells. The role of these two molecules on the control of the inflammatory response remains controversial. However, both are involved in the regulation of the T helper 17/Treg axis, suggesting their involvement in tolerance.