Combined Costimulatory and Leukocyte Functional Antigen-1 Blockade Prevents Transplant Rejection Mediated by Heterologous Immune Memory Alloresponses | Zendy

William H. Kitchens | Zendy; Divya Haridas | Zendy; Maylene E. Wagener | Zendy; Mingqing Song | Zendy; Mandy L. Ford | Zendy

Open Access

Combined Costimulatory and Leukocyte Functional Antigen-1 Blockade Prevents Transplant Rejection Mediated by Heterologous Immune Memory Alloresponses

Author(s) -

William H. Kitchens,

Divya Haridas,

Maylene E. Wagener,

Mingqing Song,

Mandy L. Ford

Publication year - 2012

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31824e75d7

Subject(s) - immunology , belatacept , lymphocytic choriomeningitis , antigen , blockade , biology , immune system , transplantation , medicine , cd8 , receptor , biochemistry , surgery , kidney transplantation , kidney transplant

Recent evidence suggests that alloreactive memory T cells are generated by the process of heterologous immunity, whereby memory T cells arising in response to pathogen infection crossreact with donor antigens. Because of their diminished requirements for costimulation during recall, these pathogen-elicited allocrossreactive memory T cells are of particular clinical importance, especially given the emergence of costimulatory blockade as a transplant immunosuppression strategy.

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