Open AccessLong-Term Effects of Alemtuzumab on Regulatory and Memory T-Cell Subsets in Kidney Transplantation
Author(s) -
Camila Macedo,
James Walters,
Elizabeth A. Orkis,
Kumiko Isse,
Beth Elinoff,
Sheila Fedorek,
J. McMichael,
Geetha Chalasani,
Parmjeet Randhawa,
Anthony J. Demetris,
Adriana Zeevi,
Henkie P. Tan,
Ron Shapiro,
Doug Landsittel,
Fadi G. Lakkis,
Diana Metes
Publication year - 2012
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318247a717
Subject(s) - alemtuzumab , term (time) , kidney transplantation , transplantation , medicine , immunology , biology , physics , quantum mechanics
Induction with lymphocyte-depleting antibodies is routinely used to prevent rejection but often skews T cells toward memory. It is not fully understood which memory and regulatory T-cell subsets are most affected and how they relate to clinical outcomes.