Open AccessFurther Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts
Author(s) -
Gunilla T. Westermark,
Alberto M. Davalli,
Antonio Secchi,
Franco Folli,
Tatsuya Kin,
Christian Toso,
A. M. James Shapiro,
Olle Korsgren,
Gunnar Tufveson,
Arne Andersson,
Per Westermark
Publication year - 2012
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31823e46ef
Subject(s) - islet , amyloid (mycology) , medicine , pathology , diabetes mellitus , endocrinology
The reasons for the long-term complete or partial loss of islet graft function are unknown, but there are obviously other reasons than just pure allogeneic graft rejection. Earlier studies have shown that deposition of islet amyloid polypeptide amyloid in transplanted islets may indicate a mechanism for loss of β cells.