Open AccessInsulin Degradation by Acinar Cell Proteases Creates a Dysfunctional Environment for Human Islets Before/After Transplantation: Benefits of α-1 Antitrypsin Treatment
Author(s) -
Gopalakrishnan Loganathan,
Rajinder Dawra,
Subbiah Pugazhenthi,
Zhixin Guo,
Sajjad Soltani,
Alexander C. Wiseman,
Mark A Sanders,
Klearchos K. Papas,
Kumaravel Velayutham,
Ashok K. Saluja,
David E.R. Sutherland,
Bernhard J. Hering,
Appakalai N. Balamurugan
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318237585c
Subject(s) - islet , proteases , insulin , medicine , transplantation , endocrinology , biology , chemistry , biochemistry , enzyme
Pancreatic acinar cells are commonly cotransplanted along with islets during auto- and allotransplantations. The aims of this study were to identify how acinar cell proteases cause human islet cell loss before and after transplantation of impure islet preparations and to prevent islet loss and improve function with supplementation of α-1 antitrypsin (A1AT).