Open AccessType I Interferon Pathway Mediates Renal Ischemia/Reperfusion Injury
Author(s) -
Maria Cecília S. Freitas,
Yoichiro Uchida,
Charles Lassman,
Gabriel M. Danovitch,
Ronald W. Busuttil,
Jerzy W. KupiecWeglinski
Publication year - 2011
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318220586e
Subject(s) - kidney , creatinine , blood urea nitrogen , endocrinology , medicine , necrosis , transplantation , reperfusion injury , receptor , acute tubular necrosis , proinflammatory cytokine , ischemia , tumor necrosis factor alpha , inflammation
Ischemia/reperfusion (I/R) injury is a common cause of acute renal failure after kidney transplantation. This study was designed to analyze the role of type I interferon (IFN) signaling downstream of Toll-like receptor 2/Toll-like receptor 4 activation in the mechanism of I/R-triggered kidney damage.