Open AccessTacrolimus and Sirolimus Induce Reproductive Abnormalities in Female Rats
Author(s) -
Vijay Shivaswamy,
LuAnn Ochsner,
Dulce Maroni,
Cheng Wang,
Joel Z. Passer,
Cara Clure,
Frederick G. Hamel,
John S. Davis,
Jennifer L. Larsen
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31821c1e8b
Subject(s) - endocrinology , medicine , immunosuppression , polycystic ovary , ovary , insulin resistance , diabetes mellitus , insulin , estrous cycle , tacrolimus , transplantation
Immunosuppression medications contribute to posttransplant diabetes mellitus in patients and can cause insulin resistance in male rats. Tacrolimus (TAC)-sirolimus (SIR) immunosuppression is also associated with appearance of ovarian cysts in transplant patients. Because insulin resistance is observed in patients with polycystic ovary syndrome, we hypothesized that TAC or SIR may induce reproductive abnormalities.