Open AccessAlloreactive CD8 T-Cell Primed/Memory Responses and Accelerated Graft Rejection in B-Cell–Deficient Sensitized Mice
Author(s) -
Hongxiu Ji,
Xiu-Da Shen,
Feng Gao,
Ronald W. Busuttil,
Yuan Zhai,
Jerzy W. KupiecWeglinski
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31821578da
Subject(s) - cd8 , cytotoxic t cell , immunology , t cell , biology , immune system , in vitro , biochemistry
The sensitized patients can develop an accelerated form of graft rejection mediated by humoral and T-cell-mediated responses, which are resistant to currently used immunosuppression.