Open AccessMemory T Cells Migrate to and Reject Vascularized Cardiac Allografts Independent of the Chemokine Receptor CXCR3
Author(s) -
Martin H. Oberbarnscheidt,
Jeffrey Walch,
Qi Li,
Amanda L. Williams,
James Walters,
Rosemary A. Hoffman,
Anthony J. Demetris,
Craig Gérard,
Geoffrey Camirand,
Fadi G. Lakkis
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31820f0856
Subject(s) - cxcr3 , immunology , cytotoxic t cell , cd8 , biology , homing (biology) , t cell , chemokine receptor , chemokine , microbiology and biotechnology , antigen , immune system , ecology , biochemistry , in vitro
Memory T cells migrate to and reject transplanted organs without the need for priming in secondary lymphoid tissues, but the mechanisms by which they do so are not known. Here, we tested whether CXCR3, implicated in the homing of effector T cells to sites of infection, is critical for memory T-cell migration to vascularized allografts.