Open AccessGeneration of Adaptive Regulatory T Cells by Alloantigen Is Required for Some But Not All Transplant Tolerance Protocols
Author(s) -
James I. Kim,
Matthew O’Connor,
Patrick E. Duff,
Gaoping Zhao,
Kang Mi Lee,
Philip Eliades,
Shaoping Deng,
Heidi Yeh,
Andrew J. Caton,
James F. Markmann
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31820e50b3
Subject(s) - foxp3 , il 2 receptor , adoptive cell transfer , immune tolerance , antigen , immunology , immune system , transplantation , peripheral tolerance , biology , in vivo , in vitro , microbiology and biotechnology , t cell , medicine , biochemistry
Because CD4CD25Foxp3 regulatory T cells (Tregs) are essential for the maintenance of self-tolerance, significant interest surrounds the developmental cues for thymic-derived natural Tregs (nTregs) and periphery-generated adaptive Tregs (aTregs). In the transplant setting, the allograft may play a role in the generation of alloantigen-specific Tregs, but this role remains undefined. We examined whether the immune response to a transplant allograft results in the peripheral generation of aTregs.