Open AccessTh17 Cells in Alemtuzumab-Treated Patients: The Effect of Long-Term Maintenance Immunosuppressive Therapy
Author(s) -
Joanna Hester,
Natalie Mills,
Sushma Shankar,
Manuela Carvalho-Gaspar,
Peter Friend,
Kathryn J. Wood
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31820c85dc
Subject(s) - alemtuzumab , medicine , term (time) , maintenance therapy , immunology , intensive care medicine , chemotherapy , antibody , physics , quantum mechanics
Leukocyte depletion at the time of transplantation with alemtuzumab (Campath-1H) has been demonstrated to be a potential strategy for reducing long-term exposure to immunosuppressive drugs. Although the impact of alemtuzumab treatment on the immune system has been explored, the effects of long-term immunosuppressive therapy in alemtuzumab-treated patients still need to be elucidated.