Open AccessMaintenance of IKKβ Activity Is Necessary to Protect Lung Grafts From Acute Injury
Author(s) -
Howard J. Huang,
Seiichiro Sugimoto,
Jessica C. Lai,
Mikio Okazaki,
Sumiharu Yamamoto,
Alexander S. Krupnick,
Daniel Kreisel,
Andrew E. Gelman
Publication year - 2011
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31820ba2a0
Subject(s) - iκb kinase , proinflammatory cytokine , inflammation , transplantation , lung , immunology , reperfusion injury , medicine , nf κb , cancer research , pharmacology , ischemia
Signaling pathways that target I-κB kinase β (IKKβ) activation stimulate the expression of nuclear factor (NF)-κB-dependent genes and are thus believed to primarily promote inflammation and injury in solid organ grafts.