Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay | Zendy

Aseda Tena | Zendy; Prashanth Vallabhajosyula | Zendy; Robert J. Hawley | Zendy; Adam Griesemer | Zendy; Kazuhiko Yamada | Zendy; David H. Sachs | Zendy

Open Access

Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay

Author(s) -

Aseda Tena,

Prashanth Vallabhajosyula,

Robert J. Hawley,

Adam Griesemer,

Kazuhiko Yamada,

David H. Sachs

Publication year - 2011

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31820b6b52

Subject(s) - baboon , biology , cd3 , t cell receptor , microbiology and biotechnology , polymerase chain reaction , transplantation , peripheral blood mononuclear cell , receptor , pathology , t cell , immunology , cd8 , gene , antigen , immune system , medicine , endocrinology , in vitro , biochemistry

Transplantation of vascularized donor thymic tissue along with a kidney transplant has markedly improved graft survival across the discordant pig-to-baboon xenogeneic barrier. To quantify the production of baboon T cells by the porcine thymic tissue, we recently developed an assay to measure the excised DNA products of baboon T-cell receptor (TCR) gene rearrangement (signal-joining TCR excision circles, sjTREC).

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